Electrogenetics | Information for Physicians

Introduction for Researchers + Physicians

The Inductive Phase State of Gene Polymer Pulsation, Compensates for the Absence of Time, Energy, and Distance Parameters of the Genetic Code

The modern genetic code is a gene base sequence theory whose regulatory influence is implied from the feedback experiments of bacterial genetics and modern mammalian genetics. Nevertheless, this intellectual framework failed to disclose the mechanics of differentiation intrinsic to understanding cell development, aging, and cancer. The weakness lies in the absence of dynamical parameters.

Since 1987 a few investigators have sought and observed other explanations at the DNA level. These reports describe energy storageand retrieval in the unstacked gene base sequences, and DNA oscillations. From measurements with Raman spectroscopy (Volkov & Kosevich), and from theoretical calculations (Bistolfi, also Prohofsky et al., also Chou et al.) an electron dynamic second DNA code emerges. I have reported that measurements with impedance spectroscopy and frequency domain analysis, confirm the oscillatory data. This concept allows the synthesis of drugs designed to act on the exchange of energy at the DNA level. The drugs act as electro-chemical reagents, demonstrating the catalytic addition of electrons to DNA. In so doing it becomes clear that a variety of protozoa and tumor cell lines suffer membrane disruption from the 250 millivolt inward current. In other parallel research, since 1983, workers at Columbia and Caltech have made abundant reports showing stacked sequences of gene bases are able to transfer photo-activated electrons within DNA in the long axis. This is a strong argument for gene to gene signaling or energy transfer when the weak current is amplified in vivo by the oscillating ion fluxes. It becomes necessary to integrate all these reactions into equivalent electronic circuitry as a cell function. To this end the impedance plots were examined from the conventions of electro-chemistry. Since DNA manifests three arcs in the upper right quadrant of the Nyquist plot, it is therefore a variable capacitor at negative voltages. At positive voltages, when exposed to a corrosion driven cation pump, DNA and RNA manifest pseudo-inductance. It is this pulsed inductive magnetic component which is capable of long range penetration of the heterogeneous biological state, and which carries cell to cell integrative biopotential feedback. Fatty acid and phospholipid electron donors are capacitative. Synthetic chemotherapy agents which transfer current to DNA and RNA share with the gene polymers a common ultra-low frequency---demonstrating resonance. These data support
models for a cellular circuit directly analogous to oscillator or tank circuits. These oscillator or pulsed circuits use a frequency at .285 Hertz -- about 17 beats/minute. It is this frequency which is believed to be responsible for the apoptosis effects of DNA reductase.

High flux oscillating electron flow produces clonal selection allowing survival of only the competent electron transfer cell systems, and therefore presents a dynamical model for the design of anti-cancer drugs.

Two catalytic chemotherapeutic agents have been synthesized: the liquid crystal polymer of palladium and lipoic acid acts as a DNA reductase and its new derivative which acts as a DNA gyrase. These have different anti-tumor spectra and receptor mechanisms. The DNA gyrase produces dense heterochromatin which is traditionally a gene suppressive action. We are studying the electrodynamics of DNA gyrase.

In summary, genetic control extends from cell to cell by long range pulsed magnetic induction according to the Faraday-Maxwell-Heaviside law:

curl B = 4 pi C

translated conceptually as:

the net circulating magnetic field around a wire or a long molecule carrying a current is equal to 4 pi times the current density.

In utilizing this electrodynamic model we are switching from traditional coulombic electrostatics to Faraday-Maxwell inductance. This may take on an intellectual adjustment period.